| 19-12, 18:00 |  Botswana Railways Highlanders – Orapa United |
26% | 20% | 54% | 12 | 5 | 3.03 | 2.94 | 2.17 | ||
| 19-12, 18:30 | Panionios – PAOK Thessaloniki |
15% | 12% | 73% | 2 | 9.30 | 4.98 | 1.28 | |||
| 19-12, 18:30 | FC Groningen – FC Utrecht |
39% | 19% | 43% | 12 | 2.76 | 3.21 | 2.34 | |||
| 19-12, 18:30 | Ismaily SC – Al-Ahly Cairo |
27% | 33% | 40% | X2 | 6.10 | 3.56 | 1.48 | |||
| 19-12, 19:00 | FC Botosani – Dinamo Bucharest |
51% | 26% | 23% | 1X | 7 | 1.79 | 3.34 | 4.14 | ||
| 19-12, 19:00 | CD Pena Azagresa – RC Celta De Vigo |
26% | 17% | 57% | 2 | 7 | 15.00 | 10.00 | 1.05 | ||
| 19-12, 19:00 | CD Melilla – Levante UD |
19% | 23% | 59% | 2 | 4 | 35.06 | 10.65 | 1.02 | ||
| 19-12, 19:00 | CA Antoniano – Real Betis |
27% | 14% | 59% | 2 | 8 | 26.07 | 10.20 | 1.04 | ||
| 19-12, 19:00 | Lleida Esportiu – RCD Espanyol Barcelona |
32% | 27% | 41% | 12 | 6.09 | 3.87 | 1.48 | |||
| 19-12, 20:30 | CD Laredo – SD Huesca |
32% | 22% | 46% | 12 | 5 | 8.44 | 4.53 | 1.31 | ||
| 19-12, 20:30 | UD Tamaraceite – UD Almeria |
33% | 26% | 41% | 12 | 5.67 | 4.04 | 1.48 | |||
| 19-12, 20:45 | RSC Anderlecht – Club Brugge |
31% | 17% | 53% | 12 | 7 | 4.28 | 3.68 | 1.68 | ||
| 19-12, 20:45 | Cambuur Leeuwarden – Feyenoord Rotterdam |
12% | 25% | 62% | 2 | 8 | 4.91 | 4.25 | 1.51 | ||
| 19-12, 21:00 | Lorca Deportiva CF – CA Osasuna |
32% | 20% | 49% | 12 | 6 | 9.13 | 5.26 | 1.25 | ||
| 19-12, 23:15 | CA Nacional Potosi – Jorge Wilstermann |
22% | 52% | 26% | X2 | 5 | 2.70 | 3.16 | 2.26 |
