| 18-12, 18:55 |  UC Sampdoria – Juventus Turin |
26% | 31% | 43% | X2 | 6.84 | 4.32 | 1.44 | |||
| 18-12, 20:00 | FC Barcelona – Real Madrid |
36% | 49% | 15% | 1X | 5 | 1.76 | 4.10 | 4.06 | ||
| 18-12, 20:00 | Guabira Montero – Royal Pari Sion |
66% | 17% | 17% | 1 | 1.81 | 3.53 | 3.41 | |||
| 18-12, 20:30 | Eintracht Frankfurt – 1. FC Köln |
55% | 23% | 21% | 1 | 5 | 1.79 | 3.79 | 4.20 | ||
| 18-12, 20:30 | SC Freiburg – Bayern Munich |
16% | 30% | 54% | X2 | 4 | 13.24 | 7.74 | 1.17 | ||
| 18-12, 20:45 | Everton – Leicester City |
33% | 35% | 32% | 2.78 | 3.41 | 2.34 | ||||
| 18-12, 20:45 | Oxford United – Manchester City |
23% | 20% | 57% | 2 | 6 | 19.72 | 9.34 | 1.08 | ||
| 18-12, 20:45 | Brescia Calcio – US Sassuolo Calcio |
26% | 37% | 36% | X2 | 2.39 | 3.53 | 2.72 | |||
| 18-12, 20:45 | Heart of Midlothian – Celtic Glasgow |
22% | 28% | 50% | X2 | 5 | 11.18 | 5.54 | 1.22 | ||
| 18-12, 21:05 | Amiens SC – FC Stade Rennes |
38% | 37% | 25% | 1X | 2.88 | 3.03 | 2.42 | |||
| 18-12, 21:05 | Olympique Nimes – AS Saint-Étienne |
20% | 20% | 61% | 2 | 4 | 3.07 | 3.11 | 2.26 | ||
| 18-12, 21:45 | Benfica Lisbon – Sporting Braga |
46% | 29% | 25% | 1X | 5 | 1.53 | 3.78 | 5.20 |
