| 21-09, 18:00 |  Hamrun Spartans FC – Sirens FC |
23% | 51% | 25% | X2 | 4 | 2.53 | 3.32 | 2.31 | ||
| 21-09, 18:30 | SV Werder Bremen – RB Leipzig |
15% | 15% | 69% | 2 | 4.04 | 4.14 | 1.75 | |||
| 21-09, 18:30 | Newcastle United – Brighton & Hove Albion FC |
33% | 34% | 34% | 2.43 | 3.08 | 3.08 | ||||
| 21-09, 18:30 | Atletico Madrid – RC Celta De Vigo |
69% | 15% | 16% | 1 | 1.42 | 4.29 | 8.03 | |||
| 21-09, 19:00 | PFC Slavia Sofia – Levski Sofia |
14% | 23% | 63% | 2 | 7 | 4.28 | 3.39 | 1.69 | ||
| 21-09, 20:00 | Stade de Reims – AS Monaco |
35% | 34% | 32% | 2.47 | 3.10 | 2.85 | ||||
| 21-09, 20:45 | AC Milan – Inter Milan |
19% | 39% | 42% | X2 | 3.38 | 3.19 | 2.17 | |||
| 21-09, 21:00 | Granada CF – FC Barcelona |
14% | 34% | 52% | X2 | 7 | 7.56 | 5.15 | 1.36 |
